Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A 		0.800 GenomicAlterations disease CGI
Entrez Id: 4286
Gene Symbol: MITF
MITF 		0.700 GenomicAlterations disease CGI
Entrez Id: 8314
Gene Symbol: BAP1
BAP1 		0.700 GenomicAlterations disease CGI
Entrez Id: 4763
Gene Symbol: NF1
NF1 		0.600 GenomicAlterations disease CGI
Entrez Id: 595
Gene Symbol: CCND1
CCND1 		0.400 GenomicAlterations disease CGI
Entrez Id: 5058
Gene Symbol: PAK1
PAK1 		0.340 GenomicAlterations disease CGI
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		1.000 CausalMutation disease CLINVAR Primary cross-resistance to BRAFV600E-, MEK1/2- and PI3K/mTOR-specific inhibitors in BRAF-mutant melanoma cells counteracted by dual pathway blockade. 26678033 2016
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		1.000 CausalMutation disease CLINVAR Combined BRAF and MEK inhibition in melanoma with BRAF V600 mutations. 23020132 2012
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		1.000 CausalMutation disease CGI
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		1.000 CausalMutation disease CLINVAR BRAF and RAS mutations in human lung cancer and melanoma. 12460918 2002
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		1.000 CausalMutation disease CLINVAR RG7204 (PLX4032), a selective BRAFV600E inhibitor, displays potent antitumor activity in preclinical melanoma models. 20551065 2010
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		1.000 CausalMutation disease CLINVAR Loss of NF1 in cutaneous melanoma is associated with RAS activation and MEK dependence. 24576830 2014
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		1.000 CausalMutation disease CLINVAR Molecular characterization of acquired resistance to the BRAF inhibitor dabrafenib in a patient with BRAF-mutant non-small-cell lung cancer. 23524406 2013
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		1.000 CausalMutation disease CLINVAR BRAF-V600 mutations have no prognostic impact in stage IV melanoma patients treated with monochemotherapy. 24586605 2014
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		1.000 CausalMutation disease CLINVAR We have treated 45 patients with V600 mutated melanoma including patients with V600R mutation between July 2011 and October 2012 with the selective BRAF inhibitor dabrafenib (n=43) or vemurafenib (n=2) via a compassionate access programme. 23237741 2013
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		1.000 CausalMutation disease CLINVAR Missense mutations of the BRAF gene in human lung adenocarcinoma. 12460919 2002
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		1.000 CausalMutation disease CLINVAR In summary, we have identified a group of melanomas with low-activity BRAF mutations that are reliant upon CRAF-mediated survival activity. 18794803 2009
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		1.000 CausalMutation disease CLINVAR Phase II study of the MEK1/MEK2 inhibitor Trametinib in patients with metastatic BRAF-mutant cutaneous melanoma previously treated with or without a BRAF inhibitor. 23248257 2013
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		1.000 CausalMutation disease CLINVAR [Long-term results following surgery or radioiodine treatment of solitary autonomous adenoma of the thyroid gland]. 2493360 1989
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		1.000 CausalMutation disease CLINVAR Dabrafenib in patients with melanoma, untreated brain metastases, and other solid tumours: a phase 1 dose-escalation trial. 22608338 2012
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		1.000 CausalMutation disease CLINVAR Prognostic value of BRAF mutations in localized cutaneous melanoma. 24388723 2014
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		1.000 CausalMutation disease CLINVAR Here we report BRAF somatic missense mutations in 66% of malignant melanomas and at lower frequency in a wide range of human cancers. 12068308 2002
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		1.000 CausalMutation disease CLINVAR Dabrafenib and trametinib, alone and in combination for BRAF-mutant metastatic melanoma. 24583796 2014
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		1.000 CausalMutation disease CLINVAR Discovery of a novel ERK inhibitor with activity in models of acquired resistance to BRAF and MEK inhibitors. 23614898 2013
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		1.000 CausalMutation disease CLINVAR Activity of the oral MEK inhibitor trametinib in patients with advanced melanoma: a phase 1 dose-escalation trial. 22805292 2012